Of Synthesis and Physicochemical Properties of Dicarboxylic Acid Dihydrazones Acetoacetanilide
Keywords:
acetoacetanilide, hydrazone, dihydrazone, dicarboxylic acids, organic synthesis, condensation reaction, IR spectroscopyAbstract
This article presents the results of the synthesis and investigation of physicochemical properties of dicarboxylic acid dihydrazones based on acetoacetanilide. During the research, dihydrazides of several dicarboxylic acids were synthesized and subsequently reacted with acetoacetanilide through condensation reactions. The obtained compounds were isolated as crystalline products and their melting points, solubility properties and spectral characteristics were determined. Infrared spectroscopy confirmed the formation of hydrazone functional groups. The obtained results indicate that the synthesized dihydrazone derivatives possess relatively high thermal stability and may be considered promising compounds for coordination chemistry and biologically active substance development.
References
Sreekanth A., Fun H.K. Synthesis, Characterization and Metal Complexes of Hydrazone Ligands Derived from Acetoacetanilide. Polyhedron, 2004, Vol. 23, pp. 2393–2400.
Huang F.X., Chen Z.M., Wang Q. Spectroscopic and Thermal Studies of Hydrazone Ligands Containing Acetoacetanilide. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2007, Vol. 68, pp. 918–926.
Rollas S., Küçükgüzel S.G. Biological Activities of Hydrazone Derivatives. Molecules, 2007, Vol. 12, pp. 1910–1939.
Singh R., Chaudhary P. Hydrazones as Versatile Ligands in Coordination Chemistry. Journal of Coordination Chemistry, 2010, Vol. 63, pp. 2361–2388.
Casas J.S., García-Tasende M.S., Sordo J. Main Group Metal Complexes of Semicarbazones and Hydrazones. Coordination Chemistry Reviews, 2000, Vol. 209, pp. 197–261.
Belskaya N.P., Dehaen W., Bakulev V.A. Synthesis and Properties of Hydrazones. Arkivoc, 2010, Issue 1, pp. 275–332.
Kumar S., Dhar D.N., Saxena P.N. Applications of Hydrazones in Medicinal Chemistry. Journal of Scientific & Industrial Research, 2009, Vol. 68, pp. 181–187.
Çakmak R., Başaran E. Synthesis of Hydrazide–Hydrazone Derivatives and Their Structural Characterization. ACS Omega, 2024, Vol. 9, pp. 20030–20041.
Hussain G., Akram S., Lateef M. Hydrazone Ligands and Their Metal Complexes: Synthesis and Characterization. Journal of Population Therapeutics and Clinical Pharmacology, 2024.
Acar Cevik U., Ünver H. New Hydrazone Derivatives: Synthesis, Characterization and Biological Studies. Zeitschrift für Naturforschung C, 2025.
Khan K.M., Rasheed M., Ullah Z. Synthesis and Biological Evaluation of Hydrazone Derivatives. Bioorganic & Medicinal Chemistry, 2003, Vol. 11, pp. 1381–1387.
Karthikeyan M.S., Prasad D.J., Poojary B. Synthesis and Antimicrobial Activity of Hydrazone Derivatives. European Journal of Medicinal Chemistry, 2006, Vol. 41, pp. 109–115.
El-Sayed N., Al-Shihri A. Spectroscopic Studies on Hydrazone Compounds and Their Complexes. Journal of Molecular Structure, 2011, Vol. 1006, pp. 191–199.
Vogel A.I. Vogel’s Textbook of Practical Organic Chemistry. 5th ed. London: Longman Scientific & Technical, 1989.
March J. Advanced Organic Chemistry: Reactions, Mechanisms and Structure. 6th ed. New York: Wiley, 2007.
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